| http://purl.uniprot.org/citations/19437337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19437337 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasmin, a major extracellular protease, activates platelets through PAR4 receptors. Plasmin-induced full aggregation is achieved at lower concentrations (0.1 U/mL) in murine platelets as compared to human platelets (1 U/mL). In COS7 cells expressing the murine PAR4 (mPAR4) receptor, 1 U/mL plasmin caused a higher intracellular calcium mobilization than in cells expressing the human PAR4 (hPAR4) receptor. This difference was reversed when the tethered ligand sequences of mPAR4 and hPAR4 were interchanged through site-directed mutagenesis. We further investigated whether PAR3 expressed in murine platelets serves as a co-receptor for PAR4 activation by plasmin. In COS7 cells, co-expressing mPAR3 and mPAR4, plamsin produced a smaller intracellular calcium mobilization compared to cells expressing mPAR4 alone, suggesting that PAR3 might inhibit plasmin-induced PAR4 stimulation. Consistent with these results, PAR3 null murine platelets also showed a greater plasmin-induced calcium mobilization and aggregation compared to wild-type murine platelets. In conclusion, murine platelets are more sensitive to activation by plasmin than human platelets due to differences in the primary sequence of PAR4. In contrast to thrombin-dependent activation of platelets, wherein PAR3 acts as a co-receptor, mPAR3 inhibits plasmin-induced PAR4 activation."xsd:string |
| http://purl.uniprot.org/citations/19437337 | http://purl.org/dc/terms/identifier | "doi:10.1080/09537100902803635"xsd:string |
| http://purl.uniprot.org/citations/19437337 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
| http://purl.uniprot.org/citations/19437337 | http://purl.uniprot.org/core/author | "Mao Y."xsd:string |
| http://purl.uniprot.org/citations/19437337 | http://purl.uniprot.org/core/author | "Kunapuli S.P."xsd:string |
| http://purl.uniprot.org/citations/19437337 | http://purl.uniprot.org/core/author | "Daniel J.L."xsd:string |
| http://purl.uniprot.org/citations/19437337 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19437337 | http://purl.uniprot.org/core/name | "Platelets"xsd:string |
| http://purl.uniprot.org/citations/19437337 | http://purl.uniprot.org/core/pages | "191-198"xsd:string |
| http://purl.uniprot.org/citations/19437337 | http://purl.uniprot.org/core/title | "Regulation of plasmin-induced protease-activated receptor 4 activation in platelets."xsd:string |
| http://purl.uniprot.org/citations/19437337 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/19437337 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19437337 |
| http://purl.uniprot.org/citations/19437337 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19437337 |
| http://purl.uniprot.org/uniprot/#_Q0VDX1-mappedCitation-19437337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19437337 |
| http://purl.uniprot.org/uniprot/#_O88634-mappedCitation-19437337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19437337 |
| http://purl.uniprot.org/uniprot/O88634 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19437337 |
| http://purl.uniprot.org/uniprot/Q0VDX1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19437337 |