| http://purl.uniprot.org/citations/19439659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19439659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19439659 | http://www.w3.org/2000/01/rdf-schema#comment | "Spatial organization of cells and their appendages is controlled by the planar cell polarity pathway, a signaling cascade initiated by the protocadherin Fat in Drosophila. Vertebrates express 4 Fat molecules, Fat1-4. We found that depletion of Fat1 caused cyst formation in the zebrafish pronephros. Knockdown of the PDZ domain containing the adaptor protein Scribble intensified the cyst-promoting phenotype of Fat1 depletion, suggesting that Fat1 and Scribble act in overlapping signaling cascades during zebrafish pronephros development. Supporting the genetic interaction with Fat1, Scribble recognized the PDZ-binding site of Fat1. Depletion of Yes-associated protein 1 (YAP1), a transcriptional co-activator inhibited by Hippo signaling, ameliorated the cyst formation in Fat1-deficient zebrafish, whereas Scribble inhibited the YAP1-induced cyst formation. Thus, reduced Hippo signaling and subsequent YAP1 disinhibition seem to play a role in the development of pronephric cysts after depletion of Fat1 or Scribble. We hypothesize that Hippo signaling is required for normal pronephros development in zebrafish and that Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0811691106"xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Mlodzik M."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Mlodzik M."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Walz G."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Walz G."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Englert C."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Englert C."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Boehlke C."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Boehlke C."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Engel C."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Engel C."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Huber T.B."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Huber T.B."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Kramer-Zucker A."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Kramer-Zucker A."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Kuehn E.W."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Kuehn E.W."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Ramachandran H."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Ramachandran H."xsd:string |
| http://purl.uniprot.org/citations/19439659 | http://purl.uniprot.org/core/author | "Simons M."xsd:string |