| http://purl.uniprot.org/citations/19439981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19439981 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundAlthough the pathogenesis of toluene diisocyanate (TDI)-induced occupational asthma (TDI-OA) is incompletely understood, several studies have suggested immunologic mechanisms, including specific IgE responses. A few studies have suggested human leukocyte antigen (HLA) associations with TDI-induced asthma in Western countries, but this is the first investigation of associations between HLA class I and II alleles and TDI-induced asthma patients in Asia, using high-resolution analysis.MethodsPatients with TDI-OA (n = 84), asymptomatic exposed controls (AECs, n = 47) and unexposed normal controls (NCs, n = 127) were enrolled. HLA class I and II genotyping was performed by the direct DNA sequencing analysis. Specific serum IgE antibodies to the vapor type TDI-albumin conjugate were measured by ELISA.ResultsThere was no significant association between the allele frequencies and the phenotype of TDI-OA. However, the frequency of the HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype was significantly higher in TDI-OA patients (19%) than in AEC (2.1%, p = 0.007, OR 4.429, CI 1.497-13.103) or NC (3.1%, p < 0.001, OR 7.235, CI 2.236-22.510) subjects, with statistical significance persisting after correction for multiple comparisons. DQB1*0402 was significantly associated with the presence of specific IgE to TDI-albumin conjugates in serum (p = 0.006, OR 4.552, CI 1.540-13.449). This p value remained significant after correction for multiple comparison.ConclusionThe HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype may be a genetic marker for the development of TDI-induced asthma in Koreans. Several HLA alleles that enhance specific IgE sensitization in exposed subjects are indicated."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.org/dc/terms/identifier | "doi:10.1159/000218118"xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/author | "Lee H.Y."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/author | "Park C.S."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/author | "Lee K.W."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/author | "Park H.S."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/author | "Kim C.W."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/author | "Hong C.S."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/author | "Choi J.H."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/author | "Hur G.Y."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/author | "Jang A.S."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/name | "Int Arch Allergy Immunol"xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/pages | "156-163"xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/title | "The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma."xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://purl.uniprot.org/core/volume | "150"xsd:string |
| http://purl.uniprot.org/citations/19439981 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19439981 |
| http://purl.uniprot.org/citations/19439981 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19439981 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19439981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19439981 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19439981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19439981 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19439981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19439981 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C545-mappedCitation-19439981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19439981 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C550-mappedCitation-19439981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19439981 |