Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/19443353http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19443353http://www.w3.org/2000/01/rdf-schema#comment"

Unlabelled

This retrospective analysis was designed to confirm the predictive role of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type I (PAI-1) in the outcome of early stage, node-negative breast cancer patients.

Patients and methods

Node-negative patients having not received adjuvant chemotherapy, and for whom frozen samples were available, were selected.

Results

Among the 169 patients included, 56.8% presented with uPA >3 ng/mg of proteins and/or PAI-1 >14 ng/mg of proteins. The median follow-up was 73 months. Significant correlations were found between uPA and disease-free survival (p [univariate]=0.003; p [multivariate]=0.01), and between uPA, PAI-1, and uPA plus PAI-1 and distant relapses (p=0.002). No significant correlation was found between uPA/PAI-1 and the risk of locoregional recurrence.

Conclusion

This study demonstrated that uPA and PAI-1 are useful predictors of distant metastases in a subset of early stage, node-negative breast cancer patients."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Stoppa-Lyonnet D."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Barillot E."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Sastre-Garau X."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"This P."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Aurias A."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Magdelenat H."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Reyal F."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Sigal-Zafrani B."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Vincent-Salomon A."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Salmon R."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Thibaut F."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Asselain B."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Fourquet A."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Poupon M.F."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Pierga J.Y."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Degeorges A."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Savignoni A."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Dieras V."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Bollet M.A."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Campana F."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Cottu P.H."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"De Cremoux P."xsd:string
http://purl.uniprot.org/citations/19443353http://purl.uniprot.org/core/author"Grandin L."xsd:string
▶