| http://purl.uniprot.org/citations/19444311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19444311 | http://www.w3.org/2000/01/rdf-schema#comment | "Plexins are receptors for axonal guidance molecules known as semaphorins. We recently reported that the semaphorin 4D (Sema4D) receptor, Plexin-B1, induces axonal growth cone collapse by functioning as an R-Ras GTPase activating protein (GAP). Here, we report that Plexin-B1 shows GAP activity for M-Ras, another member of the Ras family of GTPases. In cortical neurons, the expression of M-Ras was upregulated during dendritic development. Knockdown of endogenous M-Ras-but not R-Ras-reduced dendritic outgrowth and branching, whereas overexpression of constitutively active M-Ras, M-Ras(Q71L), enhanced dendritic outgrowth and branching. Sema4D suppressed M-Ras activity and reduced dendritic outgrowth and branching, but this reduction was blocked by M-Ras(Q71L). M-Ras(Q71L) stimulated extracellular signal-regulated kinase (ERK) activation, inducing dendrite growth, whereas Sema4D suppressed ERK activity and down-regulation of ERK was required for a Sema4D-induced reduction of dendrite growth. Thus, we conclude that Plexin-B1 is a dual functional GAP for R-Ras and M-Ras, remodelling axon and dendrite morphology, respectively."xsd:string |
| http://purl.uniprot.org/citations/19444311 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2009.63"xsd:string |
| http://purl.uniprot.org/citations/19444311 | http://purl.uniprot.org/core/author | "Fujimoto S."xsd:string |
| http://purl.uniprot.org/citations/19444311 | http://purl.uniprot.org/core/author | "Negishi M."xsd:string |
| http://purl.uniprot.org/citations/19444311 | http://purl.uniprot.org/core/author | "Saito Y."xsd:string |
| http://purl.uniprot.org/citations/19444311 | http://purl.uniprot.org/core/author | "Oinuma I."xsd:string |
| http://purl.uniprot.org/citations/19444311 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19444311 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/19444311 | http://purl.uniprot.org/core/pages | "614-621"xsd:string |
| http://purl.uniprot.org/citations/19444311 | http://purl.uniprot.org/core/title | "Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology."xsd:string |
| http://purl.uniprot.org/citations/19444311 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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