| http://purl.uniprot.org/citations/19450521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19450521 | http://www.w3.org/2000/01/rdf-schema#comment | "The transient receptor potential channel 5 (TRPC5) is predominantly expressed in the brain where it can form heterotetrameric complexes with TRPC1 and TRPC4 channel subunits. These excitatory, nonselective cationic channels are regulated by G protein, phospholipase C-coupled receptors. Here, we show that TRPC5(-/-) mice exhibit diminished innate fear levels in response to innately aversive stimuli. Moreover, mutant mice exhibited significant reductions in responses mediated by synaptic activation of Group I metabotropic glutamate and cholecystokinin 2 receptors in neurons of the amygdala. Synaptic strength at afferent inputs to the amygdala was diminished in P10-P13 null mice. In contrast, baseline synaptic transmission, membrane excitability, and spike timing-dependent long-term potentiation at cortical and thalamic inputs to the amygdala were largely normal in older null mice. These experiments provide genetic evidence that TRPC5, activated via G protein-coupled neuronal receptors, has an essential function in innate fear."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.03.039"xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Kim K.S."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Smith K.S."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Moon J."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Riccio A."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Clapham D.E."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Yao G.L."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Rodig S.J."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Rudolph U."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Bolshakov V.Y."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Tsvetkov E."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Gapon S."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Carlezon W.A. Jr."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Meloni E.G."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/author | "Van't Veer A."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/pages | "761-772"xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/title | "Essential role for TRPC5 in amygdala function and fear-related behavior."xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://purl.uniprot.org/core/volume | "137"xsd:string |
| http://purl.uniprot.org/citations/19450521 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19450521 |
| http://purl.uniprot.org/citations/19450521 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19450521 |