| http://purl.uniprot.org/citations/19451264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19451264 | http://www.w3.org/2000/01/rdf-schema#comment | "Invariant natural killer T (iNKT) cells constitute a distinct subset of T lymphocytes exhibiting important immune-regulatory functions. Although various steps of their differentiation have been well characterized, the factors controlling their development remain poorly documented. Here, we show that TGF-beta controls the differentiation program of iNKT cells. We demonstrate that TGF-beta signaling carefully and specifically orchestrates several steps of iNKT cell development. In vivo, this multifaceted role of TGF-beta involves the concerted action of different pathways of TGF-beta signaling. Whereas the Tif-1gamma branch controls lineage expansion, the Smad4 branch maintains the maturation stage that is initially repressed by a Tif-1gamma/Smad4-independent branch. Thus, these three different branches of TGF-beta signaling function in concert as complementary effectors, allowing TGF-beta to fine tune the iNKT cell differentiation program."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20090127"xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Vincent D."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Bartholin L."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Martel S."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Rimokh R."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Marie J.C."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Losson R."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Horvat B."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Benlagha K."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Yan K.P."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Doisne J.M."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Garcia C.N."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Duarte N."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Cyprian F."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/author | "Le Luduec J.B."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/pages | "1365-1378"xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/title | "iNKT cell development is orchestrated by different branches of TGF-beta signaling."xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://purl.uniprot.org/core/volume | "206"xsd:string |
| http://purl.uniprot.org/citations/19451264 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19451264 |
| http://purl.uniprot.org/citations/19451264 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19451264 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE09-mappedCitation-19451264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19451264 |