| http://purl.uniprot.org/citations/19454348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19454348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19454348 | http://www.w3.org/2000/01/rdf-schema#comment | "The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production and antiviral immunity. Here, we report that the influenza A virus nonstructural protein 1 (NS1) specifically inhibits TRIM25-mediated RIG-I CARD ubiquitination, thereby suppressing RIG-I signal transduction. A novel domain in NS1 comprising E96/E97 residues mediates its interaction with the coiled-coil domain of TRIM25, thus blocking TRIM25 multimerization and RIG-I CARD domain ubiquitination. Furthermore, a recombinant influenza A virus expressing an E96A/E97A NS1 mutant is defective in blocking TRIM25-mediated antiviral IFN response and loses virulence in mice. Our findings reveal a mechanism by which influenza virus inhibits host IFN response and also emphasize the vital role of TRIM25 in modulating antiviral defenses."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2009.04.006"xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2009.04.006"xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Inoue S."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Inoue S."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Garcia-Sastre A."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Garcia-Sastre A."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Jung J.U."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Jung J.U."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Urano T."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Urano T."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Farzan M."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Farzan M."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Huang I.-C."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Huang I.-C."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Albrecht R.A."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Albrecht R.A."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Carnero E."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Carnero E."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Gack M.U."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Gack M.U."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Inn K.-S."xsd:string |
| http://purl.uniprot.org/citations/19454348 | http://purl.uniprot.org/core/author | "Inn K.-S."xsd:string |