| http://purl.uniprot.org/citations/19454705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19454705 | http://www.w3.org/2000/01/rdf-schema#comment | "Innate mucosal immune responses, including recognition of pathogen-associated molecular patterns through Toll-like receptors, play an important role in preventing infection in the female reproductive tract (FRT). Damaged cells release nucleotides, including ATP and uridine 5'-diphosphoglucose (UDP-glucose), during inflammation and mechanical stress. We show in this report that P2RY14, a membrane receptor for UDP-glucose, is exclusively expressed in the epithelium, but not the stroma, of the FRT in humans and mice. P2RY14 and several proinflammatory cytokines, such as IL-8, are up-regulated in the endometria of patients with pelvic inflammatory disease. UDP-glucose stimulated IL-8 production via P2RY14 in human endometrial epithelial cells but not stromal cells. Furthermore, UDP-glucose enhanced neutrophil chemotaxis in the presence of a human endometrial epithelial cell line in an IL-8-dependent manner. Administration of UDP-glucose into the mouse uterus induced expression of macrophage inflammatory protein-2 and keratinocyte-derived cytokine, two murine chemokines that are functional homologues of IL-8, and augmented endometrial neutrophil recruitment. Reduced expression of P2RY14 by small interfering RNA gene silencing attenuated LPS- or UDP-glucose-induced leukocytosis in the mouse uterus. These results suggest that UDP-glucose and its receptor P2RY14 are key front line players able to trigger innate mucosal immune responses in the FRT bypassing the recognition of pathogen-associated molecular patterns. Our findings would significantly impact the strategic design of therapies to modulate mucosal immunity by targeting P2RY14."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0900001"xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Maruyama T."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Nishikawa S."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Ono M."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Oda H."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Asada H."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Yoshimura Y."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Arase T."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Masuda H."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Uchida H."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Nagashima T."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Kajitani T."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Tamaki K."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/author | "Kagami M."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/pages | "7074-7084"xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/title | "The UDP-glucose receptor P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8."xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19454705 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19454705 |
| http://purl.uniprot.org/citations/19454705 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19454705 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGB4-mappedCitation-19454705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19454705 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE58-mappedCitation-19454705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19454705 |