| http://purl.uniprot.org/citations/19457162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19457162 | http://www.w3.org/2000/01/rdf-schema#comment | "Although there is known to be a marked concentration of reactive microglia in the substantia nigra pars compacta (SNpc) of patients with Parkinson's disease (PD), a disorder in which alpha-synuclein plays a key pathogenic role, the specific roles of alpha-synuclein and microglia remains poorly understood. In this study, we investigated the effects of alpha-synuclein and the mechanisms of invasive microglial migration into the SNpc. We show that alpha-synuclein up-regulates the expressions of the cell adhesion molecule CD44 and the cell surface protease membrane-type 1 matrix metalloproteinase through the extracellular regulated kinases 1/2 pathway. These concurrent inductions increased the generation of soluble CD44 to liberate microglia from the surrounding extracellular matrix for migration. The effects of alpha-synuclein were identical in BV-2 murine microglial cells subjected to cDNA transfection and extracellular treatment. These inductions in primary microglial cultures of C57Bl/6 mice were identical to those in BV-2 cells. alpha-Synuclein-induced microglial migration into the SNpc was confirmed in vivo using a 6-hydroxydopamine mouse model of PD. Our data demonstrate a correlation between alpha-synuclein-induced phenotypic changes and microglial migration. With the recruitment of the microglial population into the SNpc during dopaminergic neurodegeneration, alpha-synuclein may play a role in accelerating the pathogenesis of PD."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2009.06075.x"xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/author | "Kim K.Y."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/author | "Park C.H."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/author | "Cho S.H."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/author | "Cho D."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/author | "Suh Y.H."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/author | "Shin K.Y."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/author | "Chang K.A."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/pages | "1483-1496"xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/title | "Alpha-synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP."xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/19457162 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19457162 |
| http://purl.uniprot.org/citations/19457162 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19457162 |
| http://purl.uniprot.org/uniprot/#_P15379-mappedCitation-19457162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19457162 |
| http://purl.uniprot.org/uniprot/#_A2APM1-mappedCitation-19457162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19457162 |
| http://purl.uniprot.org/uniprot/#_A2APM2-mappedCitation-19457162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19457162 |
| http://purl.uniprot.org/uniprot/#_A2APM3-mappedCitation-19457162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19457162 |
| http://purl.uniprot.org/uniprot/#_A2APM4-mappedCitation-19457162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19457162 |