| http://purl.uniprot.org/citations/19457859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19457859 | http://www.w3.org/2000/01/rdf-schema#comment | "Differentiation of erythroid cells requires precise control over the cell cycle to regulate the balance between cell proliferation and differentiation. The zinc finger transcription factor, erythroid Krüppel-like factor (EKLF/KLF1), is essential for proper erythroid cell differentiation and regulates many erythroid genes. Here we show that loss of EKLF leads to aberrant entry into S-phase of the cell cycle during both primitive and definitive erythropoiesis. This cell cycle defect was associated with a significant reduction in the expression levels of E2f2 and E2f4, key factors necessary for the induction of S-phase gene expression and erythropoiesis. We found and validated novel intronic enhancers in both the E2f2 and E2f4 genes, which contain conserved CACC, GATA, and E-BOX elements. The E2f2 enhancer was occupied by EKLF in vivo. Furthermore, we were able to partially restore cell cycle dynamics in EKLF(-/-) fetal liver upon additional genetic depletion of Rb, establishing a genetic causal link between reduced E2f2 and the EKLF cell cycle defect. Finally, we propose direct regulation of the E2f2 enhancer is a generic mechanism by which many KLFs regulate proliferation and differentiation."xsd:string |
| http://purl.uniprot.org/citations/19457859 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.006346"xsd:string |
| http://purl.uniprot.org/citations/19457859 | http://purl.uniprot.org/core/author | "Humbert P.O."xsd:string |
| http://purl.uniprot.org/citations/19457859 | http://purl.uniprot.org/core/author | "Perkins A.C."xsd:string |
| http://purl.uniprot.org/citations/19457859 | http://purl.uniprot.org/core/author | "Keys J.R."xsd:string |
| http://purl.uniprot.org/citations/19457859 | http://purl.uniprot.org/core/author | "Tallack M.R."xsd:string |
| http://purl.uniprot.org/citations/19457859 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19457859 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19457859 | http://purl.uniprot.org/core/pages | "20966-20974"xsd:string |
| http://purl.uniprot.org/citations/19457859 | http://purl.uniprot.org/core/title | "EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2."xsd:string |
| http://purl.uniprot.org/citations/19457859 | http://purl.uniprot.org/core/volume | "284"xsd:string |
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| http://purl.uniprot.org/uniprot/#_P56931-mappedCitation-19457859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19457859 |
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| http://purl.uniprot.org/uniprot/#_O35261-mappedCitation-19457859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19457859 |
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| http://purl.uniprot.org/uniprot/#_Q3TZQ9-mappedCitation-19457859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19457859 |