| http://purl.uniprot.org/citations/19458041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19458041 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19458041 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphatidylinositol 4-OH kinase IIIbeta (PI-4Kbeta) is involved in the regulated local synthesis of phospholipids that are crucial for trans-Golgi network (TGN)-to-plasma membrane trafficking. In this study, we show that the calcium sensor proteins calneuron-1 and calneuron-2 physically associate with PI-4Kbeta, inhibit the enzyme profoundly at resting and low calcium levels, and negatively interfere with Golgi-to-plasma membrane trafficking. At high calcium levels this inhibition is released and PI-4Kbeta is activated via a preferential association with neuronal calcium sensor-1 (NCS-1). In accord to its supposed function as a filter for subthreshold Golgi calcium transients, neuronal overexpression of calneuron-1 enlarges the size of the TGN caused by a build-up of vesicle proteins and reduces the number of axonal Piccolo-Bassoon transport vesicles, large dense core vesicles that carry a set of essential proteins for the formation of the presynaptic active zone during development. A corresponding protein knockdown has the opposite effect. The opposing roles of calneurons and NCS-1 provide a molecular switch to decode local calcium transients at the Golgi and impose a calcium threshold for PI-4Kbeta activity and vesicle trafficking."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0903001106"xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0903001106"xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Landgraf P."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Landgraf P."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Gundelfinger E.D."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Gundelfinger E.D."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Kreutz M.R."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Kreutz M.R."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Smalla K.-H."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Smalla K.-H."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Mikhaylova M."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Mikhaylova M."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Munsch T."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Munsch T."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Reddy P.P."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Reddy P.P."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Sharma Y."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Sharma Y."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Suman S.K."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/author | "Suman S.K."xsd:string |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19458041 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |