| http://purl.uniprot.org/citations/19458243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19458243 | http://www.w3.org/2000/01/rdf-schema#comment | "The presenilin-dependent gamma-secretase processing of the beta-amyloid precursor protein (betaAPP) conditions the length of the amyloid beta peptides (Abeta) that accumulate in the senile plaques of Alzheimer's disease-affected brains. This, together with an additional presenilin-mediated epsilon-secretase cleavage, generates intracellular betaAPP-derived fragments named amyloid intracellular domains (AICDs) that regulate the transcription of several genes. We establish that presenilins control the transcription of cellular prion protein (PrP(c)) by a gamma-secretase inhibitor-sensitive and AICD-mediated process. We demonstrate that AICD-dependent control of PrP(c) involves the tumor suppressor p53. Thus, p53-deficiency abolishes the AICD-mediated control of PrP(c) transcription. Furthermore, we show that p53 directly binds to the PrP(c) promoter and increases its transactivation. Overall, our study unravels a transcriptional regulation of PrP(c) by the oncogene p53 that is directly driven by presenilin-dependent formation of AICD. Furthermore, it adds support to previous reports linking secretase activities involved in betaAPP metabolism to the physiology of PrP(c)."xsd:string |
| http://purl.uniprot.org/citations/19458243 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.0789-09.2009"xsd:string |
| http://purl.uniprot.org/citations/19458243 | http://purl.uniprot.org/core/author | "Checler F."xsd:string |
| http://purl.uniprot.org/citations/19458243 | http://purl.uniprot.org/core/author | "St George-Hyslop P."xsd:string |
| http://purl.uniprot.org/citations/19458243 | http://purl.uniprot.org/core/author | "Vincent B."xsd:string |
| http://purl.uniprot.org/citations/19458243 | http://purl.uniprot.org/core/author | "Orzechowski H.D."xsd:string |
| http://purl.uniprot.org/citations/19458243 | http://purl.uniprot.org/core/author | "Sunyach C."xsd:string |
| http://purl.uniprot.org/citations/19458243 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19458243 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/19458243 | http://purl.uniprot.org/core/pages | "6752-6760"xsd:string |
| http://purl.uniprot.org/citations/19458243 | http://purl.uniprot.org/core/title | "p53-Dependent transcriptional control of cellular prion by presenilins."xsd:string |
| http://purl.uniprot.org/citations/19458243 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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