| http://purl.uniprot.org/citations/19460367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19460367 | http://www.w3.org/2000/01/rdf-schema#comment | "SPIN90 is a key regulator of actin cytoskeletal organization. Using the BioGRID(beta) database (General Repository for Interaction Datasets), we identified IRSp53 as a binding partner of SPIN90, and confirmed the in vivo formation of a SPIN90-IRSp53 complex mediated through direct association of the proline-rich domain (PRD) of SPIN90 with the SH3 domain of IRSp53. SPIN90 and IRSp53 positively cooperated to mediate Rac activation, and co-expression of SPIN90 and IRSp53 in COS-7 cells led to the complex formation of SPIN90-IRSp53 in the leading edge of cells. PDGF treatment induced strong colocalization of SPIN90 and IRSp53 at membrane protrusions. Within such PDGF-induced protrusions, knockdown of SPIN90 protein using siRNA significantly reduced lamellipodia-like protrusions as well as localization of IRSp53 at those sites. Finally, competitive inhibition of SPIN90-IRSp53 binding by SPIN90 PRD dramatically reduced ruffle formation, further suggesting that SPIN90 plays a key role in the formation of the membrane protrusions associated with cell motility."xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2009.05.010"xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/author | "Kim S.M."xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/author | "Choi J."xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/author | "Kang Y.S."xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/author | "Song W.K."xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/author | "Oh H.J."xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/author | "Chun J.S."xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/author | "Bae J.I."xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/author | "Teodorof C."xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/pages | "2410-2419"xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/title | "SPIN90-IRSp53 complex participates in Rac-induced membrane ruffling."xsd:string |
| http://purl.uniprot.org/citations/19460367 | http://purl.uniprot.org/core/volume | "315"xsd:string |
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