| http://purl.uniprot.org/citations/19462976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19462976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19462976 | http://www.w3.org/2000/01/rdf-schema#comment | "Peroxiredoxins (Prxs) are a ubiquitous family of thiol peroxidases that protect cells from peroxides and have a putative role in redox signaling. In this study, we investigated the redox properties of human Prx 3, a typical 2-Cys Prx that is localized to the mitochondrial matrix. We found that Prx 3 displayed strong reactivity with H(2)O(2), with a competitive kinetic approach generating a second order rate constant of 2 x 10(7) M(-1) s(-1). This is considerably higher than typical thiols and similar to values for other mammalian 2-Cys Prxs. In contrast, Prx 3 reacted very slowly with the thiol alkylating agents iodoacetamide and N-ethylmaleimide. Using dithiothreitol redox buffers, we measured the redox potential of Prx 3 of -290 mV. This is similar to the redox potential of mitochondrial thioredoxin 2 and is consistent with optimal operation of Prx 3 in the mitochondrial matrix."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi900558g"xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi900558g"xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/author | "Cox A.G."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/author | "Cox A.G."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/author | "Hampton M.B."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/author | "Hampton M.B."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/author | "Paton L.N."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/author | "Paton L.N."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/author | "Peskin A.V."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/author | "Peskin A.V."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/author | "Winterbourn C.C."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/author | "Winterbourn C.C."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/pages | "6495-6501"xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/pages | "6495-6501"xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/title | "Redox potential and peroxide reactivity of human peroxiredoxin 3."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/title | "Redox potential and peroxide reactivity of human peroxiredoxin 3."xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/19462976 | http://purl.uniprot.org/core/volume | "48"xsd:string |