| http://purl.uniprot.org/citations/19464966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19464966 | http://www.w3.org/2000/01/rdf-schema#comment | "The DNA damage and replication checkpoint kinase Mec1/ATR is a member of the PI3-kinase related kinases that function in response to various genotoxic stresses. The checkpoint clamp 9-1-1 (Rad9-Rad1-Hus1 in S. pombe and mammals; Ddc1-Rad17-Mec3 in S. cerevisiae) executes two distinct checkpoint functions. In S. cerevisiae, DNA-bound 9-1-1 directly activates Mec1 kinase activity, a function that has not been demonstrated in other organisms. A second, conserved activity of 9-1-1 is that of TopBP1/Cut5/Dpb11 recruitment to stalled replication sites; subsequent activation of Mec1/ATR is carried out by TopBP1/Cut5/Dpb11. Biochemical studies indicate that the mode of Mec1/ATR activation by S. cerevisiae 9-1-1 is analogous to activation by S. cerevisiae Dpb11 or by vertebrate TopBP1: activation is mediated by the intrinsically disordered C-terminal tail of each activator. The relative contributions made by multiple activators of Mec1/ATR are discussed."xsd:string |
| http://purl.uniprot.org/citations/19464966 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.dnarep.2009.03.011"xsd:string |
| http://purl.uniprot.org/citations/19464966 | http://purl.uniprot.org/core/author | "Burgers P.M."xsd:string |
| http://purl.uniprot.org/citations/19464966 | http://purl.uniprot.org/core/author | "Navadgi-Patil V.M."xsd:string |
| http://purl.uniprot.org/citations/19464966 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19464966 | http://purl.uniprot.org/core/name | "DNA Repair (Amst)"xsd:string |
| http://purl.uniprot.org/citations/19464966 | http://purl.uniprot.org/core/pages | "996-1003"xsd:string |
| http://purl.uniprot.org/citations/19464966 | http://purl.uniprot.org/core/title | "A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1."xsd:string |
| http://purl.uniprot.org/citations/19464966 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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