| http://purl.uniprot.org/citations/19471023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19471023 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnts are secreted ligands that activate several receptor-mediated signal transduction cascades. Homeostatic Wnt signaling through beta-catenin is required in adults, because either elevation or attenuation of beta-catenin function has been linked to diverse diseases. To contribute to the identification of both protein and pharmacological regulators of this pathway, we describe a combinatorial screen that merged data from a high-throughput screen of known bioactive compounds with an independent focused small interfering RNA screen. Each screen independently revealed Bruton's tyrosine kinase (BTK) as an inhibitor of Wnt-beta-catenin signaling. Loss of BTK function in human colorectal cancer cells, human B cells, zebrafish embryos, and cells derived from X-linked agammaglobulinemia patients with a mutant BTK gene resulted in elevated Wnt-beta-catenin signaling, confirming that BTK acts as a negative regulator of this pathway. From affinity purification-mass spectrometry and biochemical binding studies, we found that BTK directly interacts with a nuclear component of Wnt-beta-catenin signaling, CDC73. Further, we show that BTK increased the abundance of CDC73 in the absence of stimulation and that CDC73 acted as a repressor of beta-catenin-mediated transcription in human colorectal cancer cells and B cells."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.2000230"xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Yi X."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Biechele T.L."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Camp N.D."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Major M.B."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Arthur W.T."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Rawlings D.J."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Sommer K."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Cleary M.A."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Haggarty S.J."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "MacCoss M."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "James R.G."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Conrad W.H."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Fass D.M."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/author | "Roberts B.S."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/pages | "ra25"xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/title | "Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/19471023 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19471023 |
| http://purl.uniprot.org/citations/19471023 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19471023 |