| http://purl.uniprot.org/citations/19474209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19474209 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptor (TLR) 2 and TLR4 are major receptors of Aspergillus fumigatus. Aspergillus fumigatus signaling in cornea induces the production of many pro-inflammatory molecules. In this study, we have shown that exposure of telomerase-immortalized human corneal epithelial cells (HCECs) to A. fumigatus antigens resulted in up-regulation of TLR2 and TLR4, and release of IL-1beta and IL-10 in HCECs, effects that could be inhibited by treatment with TLR2, and TLR4 antibodies. In addition, the A. fumigatus antigens-induced production of IL-1beta and IL-10 in supernatants of corneal epithelial cells was also attenuated by NF-kappaB inhibitor. Aspergillus fumigatus keratitis developed in Wistar rats, as evidenced by high SLE scores, influx of polymorphonuclear leukocytes (PMNs), activation of TLR2 and TLR4, and production of IL-1beta and IL-10 over controls. These findings indicate that the cornea has functional TLR2 and TLR4, and activation of TLR2 and TLR4 through NF-kappaB may contribute to pathogenesis of keratomycosis."xsd:string |
| http://purl.uniprot.org/citations/19474209 | http://purl.org/dc/terms/identifier | "doi:10.1177/1753425908101521"xsd:string |
| http://purl.uniprot.org/citations/19474209 | http://purl.uniprot.org/core/author | "Wu X.Y."xsd:string |
| http://purl.uniprot.org/citations/19474209 | http://purl.uniprot.org/core/author | "Yu F.S."xsd:string |
| http://purl.uniprot.org/citations/19474209 | http://purl.uniprot.org/core/author | "Jie Zhao"xsd:string |
| http://purl.uniprot.org/citations/19474209 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19474209 | http://purl.uniprot.org/core/name | "Innate Immun"xsd:string |
| http://purl.uniprot.org/citations/19474209 | http://purl.uniprot.org/core/pages | "155-168"xsd:string |
| http://purl.uniprot.org/citations/19474209 | http://purl.uniprot.org/core/title | "Activation of Toll-like receptors 2 and 4 in Aspergillus fumigatus keratitis."xsd:string |
| http://purl.uniprot.org/citations/19474209 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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