| http://purl.uniprot.org/citations/19477204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19477204 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms by which opioids affect progression of human immunodeficiency virus type 1 (HIV-1) infection are not well-defined. HIV-1 gp120 is important in the apoptotic death of uninfected, bystander T cells. In this study, we show that co-treatment of human peripheral blood mononuclear cells (PBMC) with HIV-1 gp120/morphine synergistically induces apoptosis in PBMC. Co-treatment of murine splenocytes from mu opiate receptor knockout mice with gp120/morphine resulted in decreased apoptosis when compared to splenocytes from wild type mice. Co-treatment of human PBMC or murine splenocytes with gp120/morphine led to decreased expression of beta-arrestin 2, a protein required for opioid-mediated signaling. The role of beta-arrestin 2 was confirmed in Jurkat lymphocytes, in which 1) over-expression of beta-arrestin 2 inhibited gp120/morphine-induced apoptosis and 2) RNA interference of beta-arrestin 2 expression enhanced gp120/morphine-induced apoptosis. These data suggest a novel mechanism by which HIV-1 gp120 and opioids induce lymphocyte cell death."xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2009.05.007"xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/author | "Yin D."xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/author | "Stuart C."xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/author | "LeSage G."xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/author | "Moorman J."xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/author | "Prayther D."xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/pages | "1366-1371"xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/title | "HIV-1 gp120 primes lymphocytes for opioid-induced, beta-arrestin 2-dependent apoptosis."xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://purl.uniprot.org/core/volume | "1793"xsd:string |
| http://purl.uniprot.org/citations/19477204 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19477204 |
| http://purl.uniprot.org/citations/19477204 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19477204 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0Z2-mappedCitation-19477204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19477204 |
| http://purl.uniprot.org/uniprot/#_E9Q7D3-mappedCitation-19477204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19477204 |
| http://purl.uniprot.org/uniprot/#_E9Q7D4-mappedCitation-19477204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19477204 |
| http://purl.uniprot.org/uniprot/#_A1KZZ4-mappedCitation-19477204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19477204 |
| http://purl.uniprot.org/uniprot/#_A1KZZ6-mappedCitation-19477204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19477204 |
| http://purl.uniprot.org/uniprot/#_A1KZZ7-mappedCitation-19477204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19477204 |
| http://purl.uniprot.org/uniprot/#_A0A158SIT9-mappedCitation-19477204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19477204 |