| http://purl.uniprot.org/citations/19477525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19477525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19477525 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-10 production shows a broad-spectrum of individual response, suggesting a genetic component of approximately 75%. Different polymorphisms located close to, or within the IL-10 gene has been demonstrated to influence its transcription rate whereas the post-transcriptional regulation of IL-10 production has not well elucidated. The main responsible elements at this control level are both the 5'- and 3'-untranslated regions (UTR's) of mRNAs, and as the 3'-UTR regions are mainly involved in the stability and decay rate of mRNAs, the 5'-UTR regions mediate the binding rate of the molecule with ribosomal 40S subunit as a cis-acting element. Herein are report data on the identification of two IL10 mRNA that differ by the length of respective 5'UTR regions (160 and 288 nucleotides, respectively; EMBL accession nrs: EU751618 and EU751619) produced after stimulation of human blood samples with bacterial lipopolysaccharide (LPS). The longer 5'UTR is constitutively expressed in unstimulated PBMC cells cultured at 37 degrees C for 24h, while in LPS stimulated cells an additional IL-10 mRNA molecule, containing a shorter 5'UTR, is synthesized. RNADRAW software (http://www.rnadraw.com/) analysis have indicated that the secondary structures of the shorter 5'UTR IL-10 mRNA region is more available for the binding to the 40S ribosomal subunit. In conclusion, our data seem to suggest that LPS could influence the post-transcriptional control of IL-10 production inducing an alternative mRNA immediately available in response to the inflammatory stimulation."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/name | "Mol. Immunol."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2009.04.034"xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2009.04.034"xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19477525 |
| http://purl.uniprot.org/citations/19477525 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19477525 |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Caruso C."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Caruso C."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Barbieri R."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Barbieri R."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Bellavia D."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Bellavia D."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Forte G.I."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Forte G.I."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Lio D."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Lio D."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Sanacore M."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Sanacore M."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Scazzone C."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Scazzone C."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Scola L."xsd:string |
| http://purl.uniprot.org/citations/19477525 | http://purl.uniprot.org/core/author | "Scola L."xsd:string |