| http://purl.uniprot.org/citations/19477925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19477925 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA damage activates the ataxia telangiectasia-mutated and Rad3-related (ATR) kinase signal cascade. How this system is restrained is not understood. We find that in estrogen receptor (ER)-positive breast cancer cells, UV or ionizing radiation and hydroxyurea rapidly activate ATR-dependent phosphorylation of endogenous p53 and Chk1. 17-beta-estradiol (E(2)) substantially blocks ATR activity via plasma membrane-localized ERalpha. E(2)/ER reduces the enhanced association of ATR andTopBP1 proteins that follows DNA damage and strongly correlates to ATR activity. E(2) inhibits ATR activation through rapid PI3K/AKT signaling: AKT phosphorylates TopBP1 at Serine 1159, thereby preventing the enhanced association of ATR with TopBP1 after DNA damage. E(2) also inhibits Claspin:Chk1 protein association via AKT phosphorylation of Chk1, preventing Chk1 signaling to the G2/M checkpoint. ATR-phosphorylation of p53 induces p21 transcription, prevented by E(2)/ER. E(2) delays the assembly and prolongs the resolution of gammaH2AX and Rad51 nuclear foci and delays DNA repair. E(2)/ER also increases the chromosomal damage seen from cell exposure to IR. Therefore, the restraint of ATR cascade activation may be a novel estrogen action relevant to breast cancer."xsd:string |
| http://purl.uniprot.org/citations/19477925 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e09-01-0085"xsd:string |
| http://purl.uniprot.org/citations/19477925 | http://purl.uniprot.org/core/author | "Lee E."xsd:string |
| http://purl.uniprot.org/citations/19477925 | http://purl.uniprot.org/core/author | "Levin E.R."xsd:string |
| http://purl.uniprot.org/citations/19477925 | http://purl.uniprot.org/core/author | "Pedram A."xsd:string |
| http://purl.uniprot.org/citations/19477925 | http://purl.uniprot.org/core/author | "Razandi M."xsd:string |
| http://purl.uniprot.org/citations/19477925 | http://purl.uniprot.org/core/author | "Evinger A.J."xsd:string |
| http://purl.uniprot.org/citations/19477925 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19477925 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/19477925 | http://purl.uniprot.org/core/pages | "3374-3389"xsd:string |
| http://purl.uniprot.org/citations/19477925 | http://purl.uniprot.org/core/title | "Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair."xsd:string |
| http://purl.uniprot.org/citations/19477925 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/19477925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19477925 |
| http://purl.uniprot.org/citations/19477925 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19477925 |
| http://purl.uniprot.org/uniprot/#_O14757-mappedCitation-19477925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19477925 |
| http://purl.uniprot.org/uniprot/#_Q13535-mappedCitation-19477925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19477925 |
| http://purl.uniprot.org/uniprot/#_Q92547-mappedCitation-19477925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19477925 |
| http://purl.uniprot.org/uniprot/#_P04637-mappedCitation-19477925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19477925 |
| http://purl.uniprot.org/uniprot/Q92547 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19477925 |
| http://purl.uniprot.org/uniprot/O14757 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19477925 |
| http://purl.uniprot.org/uniprot/Q13535 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19477925 |
| http://purl.uniprot.org/uniprot/P04637 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19477925 |