| http://purl.uniprot.org/citations/19481140 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19481140 | http://www.w3.org/2000/01/rdf-schema#comment | "Tnk1/Kos1 is a non-receptor protein tyrosine kinase found to be a tumor suppressor. It negatively regulates cell growth by indirectly suppressing Ras activity. We identified and characterized the critical cis-elements required for Tnk1/Kos1's promoter activity. Results indicate that the murine Tnk1 promoter lacks a conventional TATA, CAAT or initiator element (Inr) but contains multiple transcription start sites. Transcription is initiated by a TATA-like element composed of an AT rich sequence at -30 (30 bp upstream) from the major transcription start site and an Inr-like element that overlaps the multiple start sites. Deletion analysis of the m-Tnk1 promoter reveals the presence of both positive (-25 to -151) and negative (-151 to -1201) regulatory regions. The three GC boxes which bind Sp1 and Sp3 with high affinity, an AP2 site (that overlaps with an AML1 site) and a MED1 site comprise the necessary cis-elements of the proximal promoter required for both constitutive and inducible Tnk1/Kos1 expression. Importantly, results reveal that cellular stress reverses the repression of Tnk1/Kos1 and induces its expression through increased high affinity interactions between nuclear proteins Sp1, Sp3, AP2 and MED1 for the m-Tnk1 promoter. These findings provide a mechanism by which the m-Tnk1 promoter can be dynamically regulated during normal growth."xsd:string |
| http://purl.uniprot.org/citations/19481140 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2009.05.010"xsd:string |
| http://purl.uniprot.org/citations/19481140 | http://purl.uniprot.org/core/author | "May W.S. Jr."xsd:string |
| http://purl.uniprot.org/citations/19481140 | http://purl.uniprot.org/core/author | "Reinhard M.K."xsd:string |
| http://purl.uniprot.org/citations/19481140 | http://purl.uniprot.org/core/author | "Hoare S."xsd:string |
| http://purl.uniprot.org/citations/19481140 | http://purl.uniprot.org/core/author | "Hoare K."xsd:string |
| http://purl.uniprot.org/citations/19481140 | http://purl.uniprot.org/core/author | "Flagg T.O."xsd:string |
| http://purl.uniprot.org/citations/19481140 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19481140 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/19481140 | http://purl.uniprot.org/core/pages | "1-9"xsd:string |
| http://purl.uniprot.org/citations/19481140 | http://purl.uniprot.org/core/title | "Functional characterization of the murine Tnk1 promoter."xsd:string |
| http://purl.uniprot.org/citations/19481140 | http://purl.uniprot.org/core/volume | "444"xsd:string |
| http://purl.uniprot.org/citations/19481140 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19481140 |
| http://purl.uniprot.org/citations/19481140 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19481140 |
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| http://purl.uniprot.org/uniprot/Q3TJU8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19481140 |
| http://purl.uniprot.org/uniprot/Q99ML2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19481140 |