| http://purl.uniprot.org/citations/19481527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19481527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19481527 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic proteasome consists of a core particle (CP), which degrades unfolded protein, and a regulatory particle (RP), which is responsible for recognition, ATP-dependent unfolding, and translocation of polyubiquitinated substrate protein. In the archaea Methanocaldococcus jannaschii, the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). Here, we report the crystal structures of essential elements of the archaeal proteasome: the CP, the ATPase domain of PAN, and a distal subcomplex that is likely the first to encounter substrate. The distal subcomplex contains a coiled-coil segment and an OB-fold domain, both of which appear to be conserved in the eukaryotic proteasome. The OB domains of PAN form a hexameric ring with a 13 A pore, which likely constitutes the outermost constriction of the substrate translocation channel. These studies reveal structural codes and architecture of the complete proteasome, identify potential substrate-binding sites, and uncover unexpected asymmetry in the RP of archaea and eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.04.021"xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.04.021"xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Finley D."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Finley D."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Jeffrey P.D."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Jeffrey P.D."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Tian G."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Tian G."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/pages | "473-484"xsd:string |
| http://purl.uniprot.org/citations/19481527 | http://purl.uniprot.org/core/pages | "473-484"xsd:string |