| http://purl.uniprot.org/citations/19484123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19484123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19484123 | http://www.w3.org/2000/01/rdf-schema#comment | "RIG-I and MDA5 are cytoplasmic sensors that recognize different species of viral RNAs, leads to activation of the transcription factors IRF3 and NF-kappaB, which collaborate to induce type I interferons. In this study, we identified REUL, a RING-finger protein, as a specific RIG-I-interacting protein. REUL was associated with RIG-I, but not MDA5, through its PRY and SPRY domains. Overexpression of REUL potently potentiated RIG-I-, but not MDA5-mediated downstream signalling and antiviral activity. In contrast, the RING domain deletion mutant of REUL suppressed Sendai virus (SV)-induced, but not cytoplasmic polyI:C-induced activation of IFN-beta promoter. Knockdown of endogenous REUL by RNAi inhibited SV-triggered IFN-beta expression, and also increased VSV replication. Full-length RIG-I, but not the CARD domain deletion mutant of RIG-I, underwent ubiquitination induced by REUL. The Lys 154, 164, and 172 residues of the RIG-I CARD domain were critical for efficient REUL-mediated ubiquitination, as well as the ability of RIG-I to induce activation of IFN-beta promoter. These findings suggest that REUL is an E3 ubiquitin ligase of RIG-I and specifically stimulates RIG-I-mediated innate antiviral activity."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0005760"xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0005760"xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Gao D."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Gao D."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Yang Y.K."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Yang Y.K."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Wang R.P."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Wang R.P."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Chen D.Y."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Chen D.Y."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Zhai Z.H."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Zhai Z.H."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Li M.D."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Li M.D."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Diao F.C."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Diao F.C."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Jiang Z.F."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/author | "Jiang Z.F."xsd:string |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19484123 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |