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http://purl.uniprot.org/citations/19486448http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19486448http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19486448http://www.w3.org/2000/01/rdf-schema#comment"

Background

Hepatitis C virus (HCV) core protein is a multi-functional viral protein that interacts with several target proteins of both viral and cellular origin.

Aim and methods

To gain insight into the mechanism of action of HCV core protein, we used a yeast two-hybrid system to identify the core protein-interacting cellular targets.

Results

A cDNA clone encoding an aspartoacylase was obtained, termed aspartoacylase 3 (ACY3). Interaction between ACY3 and HCV core protein was verified using a co-immunoprecipitation assay in vitro, and a mammalian two-hybrid system in vivo. Fluorescence microscopy showed green fluorescence protein-fused ACY3 localized in the cytoplasm.

Conclusion

Our data suggest that ACY3 is an HCV core binding protein, which may play a role in the development of HCV-associated diseases."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.org/dc/terms/identifier"doi:10.1111/j.1440-1746.2009.05846.x"xsd:string
http://purl.uniprot.org/citations/19486448http://purl.org/dc/terms/identifier"doi:10.1111/j.1440-1746.2009.05846.x"xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Liu M."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Liu M."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Zhang X."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Zhang X."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Shi L."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Shi L."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Ye F."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Ye F."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Chen T.Y."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Chen T.Y."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Chen Y.R."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Chen Y.R."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Dang S.S."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Dang S.S."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Lin S.M."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Lin S.M."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Zhang S.L."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Zhang S.L."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Zhao Y.R."xsd:string
http://purl.uniprot.org/citations/19486448http://purl.uniprot.org/core/author"Zhao Y.R."xsd:string
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