| http://purl.uniprot.org/citations/19487454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19487454 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have unequivocally identified multipotent stem/progenitor cells in mammary glands, offering a tractable model system to unravel genetic and epigenetic regulation of epithelial stem/progenitor cell development and homeostasis. In this study, we show that Pygo2, a member of an evolutionarily conserved family of plant homeo domain-containing proteins, is expressed in embryonic and postnatal mammary progenitor cells. Pygo2 deficiency, which is achieved by complete or epithelia-specific gene ablation in mice, results in defective mammary morphogenesis and regeneration accompanied by severely compromised expansive self-renewal of epithelial progenitor cells. Pygo2 converges with Wnt/beta-catenin signaling on progenitor cell regulation and cell cycle gene expression, and loss of epithelial Pygo2 completely rescues beta-catenin-induced mammary outgrowth. We further describe a novel molecular function of Pygo2 that is required for mammary progenitor cell expansion, which is to facilitate K4 trimethylation of histone H3, both globally and at Wnt/beta-catenin target loci, via direct binding to K4-methyl histone H3 and recruiting histone H3 K4 methyltransferase complexes."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200810133"xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Dai X."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Li A."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Yuan Y."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Sun P."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Takemaru K."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Gu B."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Rheaume C."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Bilanchone V."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Lee E.Y."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Lewis M.T."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Agrawal A."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Millar S."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Moraes R.C."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Veltmaat J.M."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/author | "Teng A."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/pages | "811-826"xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/title | "Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation."xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://purl.uniprot.org/core/volume | "185"xsd:string |
| http://purl.uniprot.org/citations/19487454 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19487454 |