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| http://purl.uniprot.org/citations/19487569 | http://www.w3.org/2000/01/rdf-schema#comment | "The selective regulation of macroautophagy remains poorly defined. Here we report that PDGFR signaling is an essential selective promoter of hypoxia-induced macroautophagy. Hypoxia-induced macroautophagy in tumor cells is also HIF1alpha-dependent, with HIF1alpha integrating signals from PDGFRs and oxygen tension. Inhibition of PDGFR signaling reduces HIF1alpha half-life, despite buffering of steady-state protein levels by a compensatory increase in HIF1alpha mRNA. This markedly changes HIF1alpha protein pool dynamics, and consequently reduces the HIF1alpha transcriptome. As autocrine growth factor signaling is a hallmark of many cancers, cell-autonomous enhancement of HIF1alpha-mediated macroautophagy may represent a mechanism for augmenting tumor cell survival under hypoxic conditions."xsd:string |
| http://purl.uniprot.org/citations/19487569 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.521709"xsd:string |
| http://purl.uniprot.org/citations/19487569 | http://purl.uniprot.org/core/author | "Wilkinson S."xsd:string |
| http://purl.uniprot.org/citations/19487569 | http://purl.uniprot.org/core/author | "Ryan K.M."xsd:string |
| http://purl.uniprot.org/citations/19487569 | http://purl.uniprot.org/core/author | "Fricker M."xsd:string |
| http://purl.uniprot.org/citations/19487569 | http://purl.uniprot.org/core/author | "O'Prey J."xsd:string |
| http://purl.uniprot.org/citations/19487569 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19487569 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/19487569 | http://purl.uniprot.org/core/pages | "1283-1288"xsd:string |
| http://purl.uniprot.org/citations/19487569 | http://purl.uniprot.org/core/title | "Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity."xsd:string |
| http://purl.uniprot.org/citations/19487569 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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