| http://purl.uniprot.org/citations/19488747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19488747 | http://www.w3.org/2000/01/rdf-schema#comment | "The antiviral cascade triggered by interferon-gamma (IFN-gamma) represents a vital event for eradicating hepatitis B virus (HBV) in experimental animals. IFN-gamma signaling is mediated through the ligand binding to IFN-gamma receptor 1 (IFNGR1). Control of IFNGR1 expression level is one of the mechanisms by which cells modulate the potency of IFN-gamma signaling. In this study, we comprehensively investigated the single nucleotide polymorphisms (SNPs) in IFNGR1 gene and correlated their occurrence to susceptibility to HBV infection in a Chinese population. A total of 983 participants, including 361 chronic hepatitis B patients, 256 individuals who had spontaneously recovered from HBV infection, and 366 healthy control subjects, were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism was used to identify seven SNPs (-611A/G, -56C/T, 40G/A, 95C/T, 130A/G, 20685A/G, 21227T/C) in IFNGR1 gene. We found that -56C and -56T allele were associated with viral clearance and viral persistence, respectively (P = 0.014). In a reporter-driven assay, we validated that the promoter variant with -56C exhibited a higher transcription level than that with -56T in HepG2 cells in a cell-type-specific pattern. We conclude that a functional -56C/T SNP in IFNGR1 promoter is associated with the clinical outcome of HBV infection in this Chinese population."xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00251-009-0377-8"xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/author | "Zeng Y."xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/author | "Yuen K.Y."xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/author | "Poon V.K."xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/author | "Zheng B.J."xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/author | "Huang J.D."xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/author | "Chen D.Q."xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/author | "Ng F."xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/pages | "423-430"xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/title | "A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection."xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://purl.uniprot.org/core/volume | "61"xsd:string |
| http://purl.uniprot.org/citations/19488747 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19488747 |
| http://purl.uniprot.org/citations/19488747 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19488747 |
| http://purl.uniprot.org/uniprot/#_P15260-mappedCitation-19488747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19488747 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3Y2-mappedCitation-19488747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19488747 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3R7-mappedCitation-19488747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19488747 |
| http://purl.uniprot.org/uniprot/#_A0A2R8Y4U4-mappedCitation-19488747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19488747 |
| http://purl.uniprot.org/uniprot/#_A1Z2M9-mappedCitation-19488747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19488747 |
| http://purl.uniprot.org/uniprot/#_A5HJZ4-mappedCitation-19488747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19488747 |