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| http://purl.uniprot.org/citations/19494003 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular topoisomerases and helicases are thought to play an essential role in herpesvirus replication and gene expression and are considered to be potential targets for antiviral therapies. Topoisomerase I (Topo I) and Topo II inhibitors can selectively inhibit Epstein-Barr virus (EBV) lytic cycle DNA replication. We found that the Topo I inhibitor camptothecin and, to a lesser extent, the Topo II inhibitor etoposide are potent inhibitors of the transcription and replication function of the EBV-encoded immediate-early protein Zta (also referred to as ZEBRA, EB1, and BZLF1). Camptothecin inhibited the Zta transcription activation of endogenous and reporter-linked viral promoters. Small interfering RNA depletion of Topo I also inhibited the Zta-dependent activation of lytic cycle DNA replication. Topo I could be coimmunoprecipitated with Zta, but this interaction was restricted to EBV-positive cells, suggesting that other viral proteins stabilize the interaction between Zta and Topo I. We also found that the RecQL1 helicase, which is known to associate with Kaposi's sarcoma-associated herpesvirus (KSHV) OriLyt, interacts with EBV OriLyt. Treatment with camptothecin reduced both Zta and RecQL1 binding to OriLyt in vivo, suggesting that Topo I promotes replication protein assembly at OriLyt."xsd:string |
| http://purl.uniprot.org/citations/19494003 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.02379-08"xsd:string |
| http://purl.uniprot.org/citations/19494003 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/19494003 | http://purl.uniprot.org/core/author | "Yuan Y."xsd:string |
| http://purl.uniprot.org/citations/19494003 | http://purl.uniprot.org/core/author | "Lieberman P.M."xsd:string |
| http://purl.uniprot.org/citations/19494003 | http://purl.uniprot.org/core/author | "Rennekamp A.J."xsd:string |
| http://purl.uniprot.org/citations/19494003 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19494003 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/19494003 | http://purl.uniprot.org/core/pages | "8090-8098"xsd:string |
| http://purl.uniprot.org/citations/19494003 | http://purl.uniprot.org/core/title | "Topoisomerase I and RecQL1 function in Epstein-Barr virus lytic reactivation."xsd:string |
| http://purl.uniprot.org/citations/19494003 | http://purl.uniprot.org/core/volume | "83"xsd:string |
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