| http://purl.uniprot.org/citations/19494137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19494137 | http://www.w3.org/2000/01/rdf-schema#comment | "Although it is widely accepted that sleep must serve an essential biological function, little is known about molecules that underlie sleep regulation. Given that insomnia is a common sleep disorder that disrupts the ability to initiate and maintain restorative sleep, a better understanding of its molecular underpinning may provide crucial insights into sleep regulatory processes. Thus, we created a line of flies using laboratory selection that share traits with human insomnia. After 60 generations, insomnia-like (ins-l) flies sleep 60 min a day, exhibit difficulty initiating sleep, difficulty maintaining sleep, and show evidence of daytime cognitive impairment. ins-l flies are also hyperactive and hyperresponsive to environmental perturbations. In addition, they have difficulty maintaining their balance, have elevated levels of dopamine, are short-lived, and show increased levels of triglycerides, cholesterol, and free fatty acids. Although their core molecular clock remains intact, ins-l flies lose their ability to sleep when placed into constant darkness. Whole-genome profiling identified genes that are modified in ins-l flies. Among those differentially expressed transcripts, genes involved in metabolism, neuronal activity, and sensory perception constituted over-represented categories. We demonstrate that two of these genes are upregulated in human subjects after acute sleep deprivation. Together, these data indicate that the ins-l flies are a useful tool that can be used to identify molecules important for sleep regulation and may provide insights into both the causes and long-term consequences of insomnia."xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.5629-08.2009"xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/author | "Shaw P.J."xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/author | "Seugnet L."xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/author | "Gottschalk L."xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/author | "Donlea J."xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/author | "Duntley S.P."xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/author | "Gimbel S.I."xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/author | "Thimgan M."xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/pages | "7148-7157"xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/title | "Identifying sleep regulatory genes using a Drosophila model of insomnia."xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/19494137 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19494137 |
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