| http://purl.uniprot.org/citations/19494297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19494297 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling from the BCR and B cell activating factor receptor (BAFF-R or BR3) differentially regulates apoptosis within early transitional (T1) and late transitional (T2; CD21(int)-T2) B cells during selection processes to generate mature B lymphocytes. However, molecular mechanisms underlying the differential sensitivity of transitional B cells to apoptosis remain unclear. In this study, we demonstrate that BCR signaling induced more long-term c-Rel activation in T2 and mature than in T1 B cells leading to increased expression of anti-apoptotic genes as well as prosurvival BAFF-R and its downstream substrate p100 (NF-kappaB2). Sustained c-Rel activation required de novo c-Rel gene transcription and translation via Btk-dependent mechanisms. Like T1 cells, mature B cells from Btk- and c-Rel-deficient mice also failed to activate these genes. These findings suggest that the gain of survival potential within transitional B cells is dependent on the ability to produce a long-term c-Rel response, which plays a critical role in T2 B cell survival and differentiation in vivo by inducing anti-apoptotic genes, BAFF-R and NF-kappaB2, an essential component for BAFF-R survival signaling. Thus, acquisition of resistance to apoptosis during transitional B cell maturation is achieved by integration of BCR and BAFF-R signals."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0803281"xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/author | "Wright J.A."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/author | "Shinners N.P."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/author | "Sen R."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/author | "Khan W.N."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/author | "Castro I."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/author | "Gerstein R.M."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/author | "Damdinsuren B."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/author | "Woodland R.T."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/author | "Carlesso G."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/author | "Hoek K.L."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/pages | "7729-7737"xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/title | "B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2."xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19494297 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19494297 |
| http://purl.uniprot.org/citations/19494297 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19494297 |
| http://purl.uniprot.org/uniprot/#_P15307-mappedCitation-19494297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19494297 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VI78-mappedCitation-19494297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19494297 |
| http://purl.uniprot.org/uniprot/#_A0A494B9Y5-mappedCitation-19494297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19494297 |
| http://purl.uniprot.org/uniprot/#_A0A494BAQ2-mappedCitation-19494297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19494297 |
| http://purl.uniprot.org/uniprot/#_A2BDW0-mappedCitation-19494297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19494297 |