| http://purl.uniprot.org/citations/19496216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19496216 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous evidence suggests that the dual-specific A kinase-anchoring protein 2 functional polymorphism (AKAP10 (A/G) I646V) influences heart rate (HR) and heart rate variability (HRV) in mice and humans (N=122) with cardiovascular disease. Here, we asked whether this AKAP10 variant predicts HR and HRV in a large sample of healthy humans. Resting HR and short-term time and frequency domain measures of HRV (5 min during paced and unpaced respiration conditions) were assessed in a U.S. community sample (N=1,033) of generally healthy men and women (age 30-54) of European ancestry. Each person was genotyped for the AKAP10 variant. As with previous work, the AKAP10 Val allele predicted greater resting HR (Paced p<.01; Unpaced p<.03) and diminished HRV (Paced ps <.05) suggesting that this variant may modulate the sensitivity of cardiac pacemaker cells to autonomic inputs, possibly conferring risk for arrhythmias and sudden cardiac death."xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1469-8986.2009.00802.x"xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/author | "Conklin B.R."xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/author | "Tingley W.G."xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/author | "Ferrell R.E."xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/author | "Jennings J.R."xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/author | "Manuck S.B."xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/author | "Muldoon M.F."xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/author | "Neumann S.A."xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/author | "Peet E."xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/author | "Shrader C.J."xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/name | "Psychophysiology"xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/pages | "466-472"xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/title | "AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans."xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/19496216 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19496216 |
| http://purl.uniprot.org/citations/19496216 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19496216 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4Y8-mappedCitation-19496216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19496216 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4Z7-mappedCitation-19496216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19496216 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z513-mappedCitation-19496216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19496216 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z551-mappedCitation-19496216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19496216 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z5A1-mappedCitation-19496216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19496216 |
| http://purl.uniprot.org/uniprot/#_B7Z2W6-mappedCitation-19496216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19496216 |