| http://purl.uniprot.org/citations/19499519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19499519 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously, we showed that CD11c defines a novel subset of CD8(+) T cells whose in vivo activity is therapeutic for arthritis; however, the mechanisms directing their development, identity of their precursors, and basis of their effector function remain unknown. Here, we show that the novel subset develops from CD11c(surface-)CD8(+) T cells and undergoes robust expansion in an antigen- and 4-1BB (CD137)-dependent manner. CD11c(+)CD8(+) T cells exist in naïve mice (<3%) with limited suppressive activity. Once activated, they suppress CD4(+) T cells in vivo and in vitro. Suppression of CD4(+) by CD11c(+)CD8(+) T cells is related to an increase in IDO activity induced in competent cells via the general control non-derepressible-2 pathway. CD11c(+)CD8(+) T cells are refractory to the effect of IDO but constrict in a novel 1-methyl D,L-tryptophan-dependent mechanism resulting in reversal of their suppressive effects. Thus, our data uncover, for the first time, the origin, development, and basis of the suppressive function of this novel CD11c(+)CD8(+) T-cell subpopulation that has many signature features of Treg."xsd:string |
| http://purl.uniprot.org/citations/19499519 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200839057"xsd:string |
| http://purl.uniprot.org/citations/19499519 | http://purl.uniprot.org/core/author | "Kim C.H."xsd:string |
| http://purl.uniprot.org/citations/19499519 | http://purl.uniprot.org/core/author | "Choi B.K."xsd:string |
| http://purl.uniprot.org/citations/19499519 | http://purl.uniprot.org/core/author | "Kwon B.S."xsd:string |
| http://purl.uniprot.org/citations/19499519 | http://purl.uniprot.org/core/author | "Vinay D.S."xsd:string |
| http://purl.uniprot.org/citations/19499519 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19499519 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19499519 | http://purl.uniprot.org/core/pages | "1552-1563"xsd:string |
| http://purl.uniprot.org/citations/19499519 | http://purl.uniprot.org/core/title | "Origins and functional basis of regulatory CD11c+CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/19499519 | http://purl.uniprot.org/core/volume | "39"xsd:string |
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