| http://purl.uniprot.org/citations/19506028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19506028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19506028 | http://www.w3.org/2000/01/rdf-schema#comment | "The ardA gene, found in many prokaryotes including important pathogenic species, allows associated mobile genetic elements to evade the ubiquitous Type I DNA restriction systems and thereby assist the spread of resistance genes in bacterial populations. As such, ardA contributes to a major healthcare problem. We have solved the structure of the ArdA protein from the conjugative transposon Tn916 and find that it has a novel extremely elongated curved cylindrical structure with defined helical grooves. The high density of aspartate and glutamate residues on the surface follow a helical pattern and the whole protein mimics a 42-base pair stretch of B-form DNA making ArdA by far the largest DNA mimic known. Each monomer of this dimeric structure comprises three alpha-beta domains, each with a different fold. These domains have the same fold as previously determined proteins possessing entirely different functions. This DNA mimicry explains how ArdA can bind and inhibit the Type I restriction enzymes and we demonstrate that 6 different ardA from pathogenic bacteria can function in Escherichia coli hosting a range of different Type I restriction systems."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkp478"xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkp478"xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Carter L.G."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Carter L.G."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Dryden D.T."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Dryden D.T."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Johnson K.A."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Johnson K.A."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "McMahon S.A."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "McMahon S.A."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Naismith J.H."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Naismith J.H."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Oke M."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Oke M."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Walkinshaw M.D."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Walkinshaw M.D."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "White J.H."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "White J.H."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Blakely G.W."xsd:string |
| http://purl.uniprot.org/citations/19506028 | http://purl.uniprot.org/core/author | "Blakely G.W."xsd:string |