| http://purl.uniprot.org/citations/19506243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19506243 | http://www.w3.org/2000/01/rdf-schema#comment | "Anaphylactic shock is characterized by elevated immunoglobulin-E (IgE) antibodies that signal via the high affinity Fc epsilon receptor (Fc epsilonRI) to release inflammatory mediators. Here we report that the novel cytokine interleukin-33 (IL-33) potently induces anaphylactic shock in mice and is associated with the symptom in humans. IL-33 is a new member of the IL-1 family and the ligand for the orphan receptor ST2. In humans, the levels of IL-33 are substantially elevated in the blood of atopic patients during anaphylactic shock, and in inflamed skin tissue of atopic dermatitis patients. In murine experimental atopic models, IL-33 induced antigen-independent passive cutaneous and systemic anaphylaxis, in a T cell-independent, mast cell-dependent manner. In vitro, IL-33 directly induced degranulation, strong eicosanoid and cytokine production in IgE-sensitized mast cells. The molecular mechanisms triggering these responses include the activation of phospholipase D1 and sphingosine kinase1 to mediate calcium mobilization, Nuclear factor-kappaB activation, cytokine and eicosanoid secretion, and degranulation. This report therefore reveals a hitherto unrecognized pathophysiological role of IL-33 and suggests that IL-33 may be a potential therapeutic target for anaphylaxis, a disease of considerable unmet medical need."xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0901206106"xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/author | "Xu D."xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/author | "Liew F.Y."xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/author | "Pitman N."xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/author | "McKenzie A."xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/author | "Melendez A.J."xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/author | "Tay H.K."xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/author | "H'ng S.C."xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/author | "Pushparaj P.N."xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/pages | "9773-9778"xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/title | "The cytokine interleukin-33 mediates anaphylactic shock."xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19506243 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19506243 |
| http://purl.uniprot.org/citations/19506243 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19506243 |
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| http://purl.uniprot.org/uniprot/#_G3UYU3-mappedCitation-19506243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19506243 |
| http://purl.uniprot.org/uniprot/#_P15919-mappedCitation-19506243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19506243 |
| http://purl.uniprot.org/uniprot/#_Q3UM53-mappedCitation-19506243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19506243 |
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| http://purl.uniprot.org/uniprot/#_P14719-mappedCitation-19506243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19506243 |
| http://purl.uniprot.org/uniprot/#_Q3TR87-mappedCitation-19506243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19506243 |