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http://purl.uniprot.org/citations/19506792http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19506792http://www.w3.org/2000/01/rdf-schema#comment"

Summary

A cohort of postmenopausal osteoporotic females and controls with normal bone mineral density, the interleukin 6 (IL6) -634G > C (rs1800796) C allele of the promoter region showed association with osteoporosis. The lipoprotein receptor-related protein 5 (LRP5) gene showed association between C135242T C/T alleles and osteoporosis only in smokers, suggesting a role for environmental interaction.

Introduction

A nested case-control study within a population-based cohort was undertaken to assess the relative impact of cigarette smoking, statin use, genetic polymorphisms, and one-way interaction of these factors on development of osteoporosis in postmenopausal women.

Methods

Genotyping of 14 single-nucleotide polymorphisms (SNPs) corresponding to vitamin D receptor gene, estrogen receptor 1, collagen type 1 alpha 1, IL6, transcription growth factor beta, apolipoprotein E, and LRP5 genes was performed in cases (n = 309) with osteoporosis and controls (n = 293) with normal bone mineral density drawn from a homogeneous Caucasian population. SNPs were chosen based on known functional consequences or prior evidence for association and genotyped using matrix-assisted laser desorption ionization time-of-flight technology.

Results

Cases differed from controls relative to body mass index, age, and smoking but not statin use. After adjusting for age, the IL6 -634G > C (rs1800796) allele showed association with osteoporosis (odds ratio (OR) for CC + CG = 2.51, p = 0.0047)), independent of statin use or smoking status. On stratification for smoking, association with LRP5 C135242T (rs545382) and osteoporosis emerged (OR 2.8 in smokers for CT alleles, p = 0.03)), suggestive of potential environmental interaction.

Conclusion

Evidence suggested a role for genetic variation in IL6 and LRP5 in conferring risk for osteoporosis in Caucasian women, with the latter manifest only in smokers."xsd:string
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http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/author"Liu J."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/author"Wilson D."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/author"Shuldiner A."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/author"Giampietro P.F."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/author"Ghebranious N."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/author"Mukesh B."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/author"McCarty C."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/author"Ivacic L."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/author"Kitchner T."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/author"LeVasseur J."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/author"McKiernan F."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/name"Osteoporos Int"xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/pages"467-477"xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/title"The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort."xsd:string
http://purl.uniprot.org/citations/19506792http://purl.uniprot.org/core/volume"21"xsd:string
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