| http://purl.uniprot.org/citations/19513565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19513565 | http://www.w3.org/2000/01/rdf-schema#comment | "Decreased expression levels of EPHB6, a member of the receptor tyrosine kinases (RTKs), are associated with an increased risk of metastasis development in early stage non-small cell lung cancer (NSCLC). However, the signaling properties of the kinase-defective EPHB6 receptor are not well-understood. Here, we show that expression of EPHB6 in A549 lung adenocarcinoma cells led to phosphorylation of the MAP kinase ERK. Conversely, siRNA based knockdown of EPHB6 reversed ERK phosphorylation. Intriguingly, EPHB6-induced phosphorylation of ERK was uncoupled by activation of the Elk-1 transcriptional factor. These analyses suggest that kinase defective EPHB6 can lead to MAPK activation."xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijo_00000326"xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/author | "Berdel W.E."xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/author | "Muller-Tidow C."xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/author | "Ji P."xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/author | "Koschmieder S."xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/author | "Bulk E."xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/author | "Hascher A."xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/name | "Int J Oncol"xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/pages | "175-179"xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/title | "The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma."xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/19513565 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19513565 |
| http://purl.uniprot.org/citations/19513565 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19513565 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JNC5-mappedCitation-19513565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19513565 |
| http://purl.uniprot.org/uniprot/#_O15197-mappedCitation-19513565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19513565 |
| http://purl.uniprot.org/uniprot/#_F8WCM8-mappedCitation-19513565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19513565 |
| http://purl.uniprot.org/uniprot/#_J3KQU5-mappedCitation-19513565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19513565 |
| http://purl.uniprot.org/uniprot/O15197 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19513565 |
| http://purl.uniprot.org/uniprot/F8WCM8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19513565 |
| http://purl.uniprot.org/uniprot/J3KQU5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19513565 |
| http://purl.uniprot.org/uniprot/A0A0G2JNC5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19513565 |