| http://purl.uniprot.org/citations/19514647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19514647 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunoglobulin E (IgE) and the high affinity IgE receptor (FcepsilonRI) have been suggested to contribute to the pathogenesis of autoimmune disorders. Their role in Wegener's granulomatosis (WG) are, however, poorly recognized. We sought a genetic association between laboratory markers for the disease, i.e. anti-proteinase 3 antibodies (anti-PR3), anti-myeloperoxidase antibodies, anti-cyclic citrullinated peptide antibodies, C-reactive protein (CRP), C3c and C4 complement components, and total serum IgE levels in WG subjects with common genetic variants of FcepsilonRI subunits. Anti-PR3 and CRP and serum IgE levels showed significant associations, while complement components tended to be associated, with -18483A > C and/or -344C > T FCER1A (FcepsilonRI alpha-subunit gene) polymorphisms. Moreover, a correlation between -109T > C FCER1B (FcepsilonRI beta-subunit gene) genotypes and serum IgE was observed. Both WG specific auto-antibodies and other blood inflammatory markers displayed correlations with serum total IgE levels and genetic variants of the high affinity receptor for this immunoglobulin. This observation suggests a functional relantionship of FcepsilonRI in the regulation of autoimmune response observed in WG."xsd:string |
| http://purl.uniprot.org/citations/19514647 | http://purl.uniprot.org/core/author | "Sanak M."xsd:string |
| http://purl.uniprot.org/citations/19514647 | http://purl.uniprot.org/core/author | "Musial J."xsd:string |
| http://purl.uniprot.org/citations/19514647 | http://purl.uniprot.org/core/author | "Szczeklik A."xsd:string |
| http://purl.uniprot.org/citations/19514647 | http://purl.uniprot.org/core/author | "Potaczek D.P."xsd:string |
| http://purl.uniprot.org/citations/19514647 | http://purl.uniprot.org/core/author | "Sznajd J."xsd:string |
| http://purl.uniprot.org/citations/19514647 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19514647 | http://purl.uniprot.org/core/name | "Pol Arch Med Wewn"xsd:string |
| http://purl.uniprot.org/citations/19514647 | http://purl.uniprot.org/core/pages | "170-174"xsd:string |
| http://purl.uniprot.org/citations/19514647 | http://purl.uniprot.org/core/title | "Genetic associations of variants of the high affinity receptor for immunoglobulin E in Wegener's granulomatosis."xsd:string |
| http://purl.uniprot.org/citations/19514647 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/19514647 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19514647 |
| http://purl.uniprot.org/citations/19514647 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19514647 |
| http://purl.uniprot.org/uniprot/#_P12319-mappedCitation-19514647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19514647 |
| http://purl.uniprot.org/uniprot/#_Q6GU38-mappedCitation-19514647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19514647 |
| http://purl.uniprot.org/uniprot/#_Q8WYP6-mappedCitation-19514647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19514647 |
| http://purl.uniprot.org/uniprot/P12319 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19514647 |
| http://purl.uniprot.org/uniprot/Q8WYP6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19514647 |
| http://purl.uniprot.org/uniprot/Q6GU38 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19514647 |