| http://purl.uniprot.org/citations/19520061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19520061 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we evaluated the signaling ability of SIGNR1 in murine macrophage-like RAW264.7 cells that stably expressed FLAG-tagged SIGNR1 (SIGNR1-FLAG). Cross-linking of SIGNR1-FLAG expressed on the cells by an anti-FLAG antibody induced JNK phosphorylation without induction of phosphorylation of ERK1/2 and p38 MAP kinase, and led to phosphorylations of Src family kinases (SFKs) and Akt. The SIGNR1-FLAG molecules in the cells were found in lipid raft-enriched membrane fractions, and the tyrosine kinases Lyn, Hck, and Fgr co-precipitated with SIGNR1-FLAG in the lipid raft fractions. The antibody-induced JNK phosphorylation was inhibited by inhibitors of SFKs and tyrosine kinases. Furthermore, cross-linking of SIGNR1 led to production of TNF-alpha, and the JNK inhibitor inhibited the antibody-induced TNF-alpha production. These results show that cross-linking of SIGNR1 triggers phosphorylation of SFKs, which leads to activation of the JNK pathway and induction of TNF-alpha production in macrophage-like RAW264.7 cells."xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2009.06.011"xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://purl.uniprot.org/core/author | "Kato C."xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://purl.uniprot.org/core/author | "Ishii M."xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://purl.uniprot.org/core/author | "Kojima N."xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://purl.uniprot.org/core/author | "Kajiwara T."xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://purl.uniprot.org/core/author | "Numazaki M."xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://purl.uniprot.org/core/author | "Kawauchi Y."xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19520061 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://purl.uniprot.org/core/pages | "202-206"xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://purl.uniprot.org/core/title | "Cross-linking of SIGNR1 activates JNK and induces TNF-alpha production in RAW264.7 cells that express SIGNR1."xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://purl.uniprot.org/core/volume | "386"xsd:string |
| http://purl.uniprot.org/citations/19520061 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19520061 |
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