| http://purl.uniprot.org/citations/19520808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19520808 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemokines mediate the signaling and migration of T cells, but little is known about the transcriptional events involved therein. Microarray analysis of CXC chemokine ligand (CXCL) 12-treated T cells revealed that Wnt ligands are significantly up-regulated during CXCL12 treatment. Real-time polymerase chain reaction and Western blot analysis confirmed that the expression of noncanonical Wnt pathway members (eg, Wnt5A) was specifically up-regulated during CXCL12 stimulation, whereas beta-catenin and canonical Wnt family members were selectively down-regulated. Wnt5A augmented signaling through the CXCL12-CXCR4 axis via the activation of protein kinase C. Moreover, Wnt5A expression was required for CXCL12-mediated T-cell migration, and rWnt5A sensitized human T cells to CXCL12-induced migration. Furthermore, Wnt5A expression was also required for the sustained expression of CXCR4. These results were further supported in vivo using EL4 thymoma metastasis as a model of T-cell migration. Together, these data demonstrate that Wnt5A is a critical mediator of CXCL12-CXCR4 signaling and migration in human and murine T cells."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-08-175869"xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Patel K."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Lustig A."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Becker K.G."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Taub D.D."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Ghosh M.C."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Carter A."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "O'Connell M.P."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "French A.D."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Weeraratna A.T."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Brill M."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Wood W.W."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Collins G.D."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Vandanmagsar B."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/author | "Emeche C.D."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/pages | "1366-1373"xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/title | "Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration."xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/19520808 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19520808 |
| http://purl.uniprot.org/citations/19520808 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19520808 |