| http://purl.uniprot.org/citations/19520846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19520846 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant Wnt signaling promotes oncogenesis by increasing cellular levels of beta-catenin, which associates with DNA-bound transcription factors and activates Wnt target genes. However, the molecular mechanism by which beta-catenin mediates gene expression is still poorly understood. Here, we show that cell cycle and apoptosis regulator 1 (CCAR1), which was recently shown to function as a transcriptional coactivator for nuclear receptors, also interacts with beta-catenin and enhances the ability of beta-catenin to activate expression of transiently transfected reporter genes. Furthermore, association of CCAR1 with the promoter of an endogenous Wnt/beta-catenin target gene in a colon cancer cell line depends on the presence of beta-catenin. Depletion of CCAR1 inhibits expression of several Wnt/beta-catenin target genes and suppresses anchorage-independent growth of the colon cancer cell line. Thus, CCAR1 is a novel component of Wnt/beta-catenin signaling that plays an important role in transcriptional regulation by beta-catenin and that, therefore, may represent a novel target for therapeutic intervention in cancers involving aberrantly activated Wnt/beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/19520846 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.014332"xsd:string |
| http://purl.uniprot.org/citations/19520846 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/19520846 | http://purl.uniprot.org/core/author | "Ou C.Y."xsd:string |
| http://purl.uniprot.org/citations/19520846 | http://purl.uniprot.org/core/author | "Stallcup M.R."xsd:string |
| http://purl.uniprot.org/citations/19520846 | http://purl.uniprot.org/core/author | "Yang C.K."xsd:string |
| http://purl.uniprot.org/citations/19520846 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19520846 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19520846 | http://purl.uniprot.org/core/pages | "20629-20637"xsd:string |
| http://purl.uniprot.org/citations/19520846 | http://purl.uniprot.org/core/title | "Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/19520846 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19520846 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19520846 |
| http://purl.uniprot.org/citations/19520846 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19520846 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGG8-mappedCitation-19520846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19520846 |
| http://purl.uniprot.org/uniprot/#_B4DSW9-mappedCitation-19520846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19520846 |
| http://purl.uniprot.org/uniprot/#_B2ZRE2-mappedCitation-19520846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19520846 |
| http://purl.uniprot.org/uniprot/#_B2ZRG2-mappedCitation-19520846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19520846 |
| http://purl.uniprot.org/uniprot/#_B4DGU4-mappedCitation-19520846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19520846 |
| http://purl.uniprot.org/uniprot/#_B4DL06-mappedCitation-19520846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19520846 |
| http://purl.uniprot.org/uniprot/#_B5BU28-mappedCitation-19520846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19520846 |
| http://purl.uniprot.org/uniprot/#_G9GAG7-mappedCitation-19520846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19520846 |
| http://purl.uniprot.org/uniprot/#_P35222-mappedCitation-19520846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19520846 |
| http://purl.uniprot.org/uniprot/#_Q8IX12-mappedCitation-19520846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19520846 |
| http://purl.uniprot.org/uniprot/Q8IX12 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19520846 |