| http://purl.uniprot.org/citations/19522876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19522876 | http://www.w3.org/2000/01/rdf-schema#comment | "With more marginal deceased donors affecting graft viability, there is a need for specific parameters to assess kidney graft quality at the time of organ procurement in the deceased donor. Recently, kidney injury molecule-1 (Kim-1) was described as an early biomarker of renal proximal tubular damage. We assessed Kim-1 in a small animal brain death model as an early and noninvasive marker for donor-derived injury related to brain death and its sequelae, with subsequent confirmation in human donors. In rat kidney, real-time PCR revealed a 46-fold Kim-1 gene upregulation after 4 h of brain death. In situ hybridization showed proximal tubular Kim-1 localization, which was confirmed by immunohistochemistry. Also, Luminex assay showed a 6.6-fold Kim-1 rise in urine after 4 h of brain death. In human donors, 2.5-fold kidney injury molecule-1 (KIM-1) gene upregulation and 2-fold higher urine levels were found in donation after brain death (DBD) donors compared to living kidney donors. Multiple regression analysis showed that urinary KIM-1 at brain death diagnosis was a positive predictor of recipient serum creatinine, 14 days (p < 0.001) and 1 year (p < 0.05) after kidney transplantation. In conclusion, we think that Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage."xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-6143.2009.02713.x"xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/author | "van Goor H."xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/author | "Bonventre J.V."xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/author | "Schuurs T.A."xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/author | "Vaidya V.S."xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/author | "Leuvenink H.G."xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/author | "van der Heide J.J."xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/author | "Damman J."xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/author | "Ploeg R.J."xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/author | "Nijboer W.N."xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/name | "Am J Transplant"xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/pages | "1752-1759"xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/title | "Kidney injury molecule-1 is an early noninvasive indicator for donor brain death-induced injury prior to kidney transplantation."xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/19522876 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19522876 |
| http://purl.uniprot.org/citations/19522876 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19522876 |
| http://purl.uniprot.org/uniprot/O54947#attribution-E7BEA25A2D777DC4D5F33ED5CC17A8E2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19522876 |
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| http://purl.uniprot.org/uniprot/#_O54947-mappedCitation-19522876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19522876 |
| http://purl.uniprot.org/uniprot/O54947 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19522876 |
| http://purl.uniprot.org/uniprot/A0A8I5Y0B2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19522876 |