| http://purl.uniprot.org/citations/19525941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19525941 | http://www.w3.org/2000/01/rdf-schema#comment | "Selected vulnerability of neurons in Huntington's disease suggests that alterations occur in a cellular process that is particularly critical for neuronal function. Supporting this idea, pathogenic Htt (polyQ-Htt) inhibits fast axonal transport (FAT) in various cellular and animal models of Huntington's disease (mouse and squid), but the molecular basis of this effect remains unknown. We found that polyQ-Htt inhibited FAT through a mechanism involving activation of axonal cJun N-terminal kinase (JNK). Accordingly, we observed increased activation of JNK in vivo in cellular and mouse models of Huntington's disease. Additional experiments indicated that the effects of polyQ-Htt on FAT were mediated by neuron-specific JNK3 and not by ubiquitously expressed JNK1, providing a molecular basis for neuron-specific pathology in Huntington's disease. Mass spectrometry identified a residue in the kinesin-1 motor domain that was phosphorylated by JNK3 and this modification reduced kinesin-1 binding to microtubules. These data identify JNK3 as a critical mediator of polyQ-Htt toxicity and provide a molecular basis for polyQ-Htt-induced inhibition of FAT."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2346"xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Han D."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Huang C.F."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Yoshioka K."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Pigino G."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Liu K."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Kaminska A."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Banker G."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Brady S.T."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Bjorkblom B."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Coffey E.T."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Bagnato C."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Morfini G.A."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "Pollema S.L."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/author | "You Y.M."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/pages | "864-871"xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/title | "Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin."xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/19525941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19525941 |
| http://purl.uniprot.org/citations/19525941 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19525941 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JG69-mappedCitation-19525941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19525941 |