| http://purl.uniprot.org/citations/19526250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19526250 | http://www.w3.org/2000/01/rdf-schema#comment | "Postprandial triglyceridemia is an emerging risk factor for cardiovascular disease. However, most of the genes that influence postprandial triglyceridemia are not known. We evaluated whether a common nonsynonymous SNP rs1260326/P446L in the glucokinase regulatory protein (GCKR) gene influenced variation in the postprandial lipid response after a high-fat challenge in seven hundred and seventy participants in the Amish HAPI Heart Study who underwent an oral high-fat challenge and had blood samples taken in the fasting state and during the postprandial phase at 1, 2, 3, 4, and 6 h. We found that the minor T allele at rs1260326 was associated with significantly higher fasting TG levels after adjusting for age, sex, and family structure (P (a) = 0.06 for additive model, and P (r) = 0.0003 for recessive model). During the fat challenge, the T allele was associated with significantly higher maximum TG level (P (a) = 0.006), incremental maximum TG level (P (a) = 0.006), TG area under the curve (P (a) = 0.02) and incremental TG area under the curve (P (a) = 0.03). Our data indicate that the rs1260326 T allele of GCKR is associated with both higher fasting levels of TG as well as the postprandial TG response, which may result in higher atherogenic risk."xsd:string |
| http://purl.uniprot.org/citations/19526250 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00439-009-0700-3"xsd:string |
| http://purl.uniprot.org/citations/19526250 | http://purl.uniprot.org/core/author | "Shen H."xsd:string |
| http://purl.uniprot.org/citations/19526250 | http://purl.uniprot.org/core/author | "Mitchell B.D."xsd:string |
| http://purl.uniprot.org/citations/19526250 | http://purl.uniprot.org/core/author | "Shuldiner A.R."xsd:string |
| http://purl.uniprot.org/citations/19526250 | http://purl.uniprot.org/core/author | "McLenithan J.C."xsd:string |
| http://purl.uniprot.org/citations/19526250 | http://purl.uniprot.org/core/author | "Damcott C.M."xsd:string |
| http://purl.uniprot.org/citations/19526250 | http://purl.uniprot.org/core/author | "Pollin T.I."xsd:string |
| http://purl.uniprot.org/citations/19526250 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19526250 | http://purl.uniprot.org/core/name | "Hum Genet"xsd:string |
| http://purl.uniprot.org/citations/19526250 | http://purl.uniprot.org/core/pages | "567-574"xsd:string |
| http://purl.uniprot.org/citations/19526250 | http://purl.uniprot.org/core/title | "Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study."xsd:string |
| http://purl.uniprot.org/citations/19526250 | http://purl.uniprot.org/core/volume | "126"xsd:string |
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