| http://purl.uniprot.org/citations/19529763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19529763 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundSorting nexins (SNXs) constitute a family of proteins classified by their phosphatidylinositol (PI) binding Phox homology (PX) domain. Some members regulate intracellular trafficking. We have here investigated mechanisms underlying SNX4 mediated endosome to Golgi transport.Methodology/principal findingsWe show that SNX4 forms complexes with clathrin and dynein. The interactions were inhibited by wortmannin, a PI3-kinase inhibitor, suggesting that they form when SNX4 is associated with PI(3)P on endosomes. We further localized the clathrin interacting site on SNX4 to a clathrin box variant. A short peptide containing this motif was sufficient to pull down both clathrin and dynein. Knockdown studies demonstrated that clathrin is not required for the SNX4/dynein interaction. Moreover, clathrin knockdown led to increased Golgi transport of the toxin ricin, as well as redistribution of endosomes.Conclusions/significanceWe discuss the possibility of clathrin serving as a regulator of SNX4-dependent transport. Upon clathrin release, dynein may bind SNX4 and mediate retrograde movement."xsd:string |
| http://purl.uniprot.org/citations/19529763 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0005935"xsd:string |
| http://purl.uniprot.org/citations/19529763 | http://purl.uniprot.org/core/author | "Skanland S.S."xsd:string |
| http://purl.uniprot.org/citations/19529763 | http://purl.uniprot.org/core/author | "Brech A."xsd:string |
| http://purl.uniprot.org/citations/19529763 | http://purl.uniprot.org/core/author | "Walchli S."xsd:string |
| http://purl.uniprot.org/citations/19529763 | http://purl.uniprot.org/core/author | "Sandvig K."xsd:string |
| http://purl.uniprot.org/citations/19529763 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19529763 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/19529763 | http://purl.uniprot.org/core/pages | "e5935"xsd:string |
| http://purl.uniprot.org/citations/19529763 | http://purl.uniprot.org/core/title | "SNX4 in complex with clathrin and dynein: implications for endosome movement."xsd:string |
| http://purl.uniprot.org/citations/19529763 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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