| http://purl.uniprot.org/citations/19531493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19531493 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuropeptide signaling at the cell surface is regulated by metalloendopeptidases, which degrade peptides in the extracellular fluid, and beta-arrestins, which interact with G protein-coupled receptors (GPCRs) to mediate desensitization. beta-Arrestins also recruit GPCRs and mitogen-activated protein kinases to endosomes to allow internalized receptors to continue signaling, but the mechanisms regulating endosomal signaling are unknown. We report that endothelin-converting enzyme-1 (ECE-1) degrades substance P (SP) in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling. ECE-1 inhibition caused endosomal retention of the SP neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus, whereas ECE-1 overexpression attenuated ERK2 activation. ECE-1 inhibition also enhanced SP-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death. Thus, endosomal ECE-1 attenuates ERK2-mediated SP signaling in the nucleus to prevent cell death. We propose that agonist availability in endosomes, here regulated by ECE-1, controls beta-arrestin-dependent signaling of endocytosed GPCRs."xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.026674"xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/author | "Hardt M."xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/author | "Murphy J.E."xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/author | "Bunnett N.W."xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/author | "Steinhoff M."xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/author | "Cottrell G.S."xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/author | "Roosterman D."xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/author | "Padilla B.E."xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/author | "Amadesi S."xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/author | "Poole D.P."xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/pages | "22411-22425"xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/title | "Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling."xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19531493 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19531493 |
| http://purl.uniprot.org/citations/19531493 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19531493 |
| http://purl.uniprot.org/uniprot/#_E0CY53-mappedCitation-19531493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19531493 |
| http://purl.uniprot.org/uniprot/#_E0CYB1-mappedCitation-19531493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19531493 |
| http://purl.uniprot.org/uniprot/#_E0CZB7-mappedCitation-19531493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19531493 |
| http://purl.uniprot.org/uniprot/#_P63085-mappedCitation-19531493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19531493 |
| http://purl.uniprot.org/uniprot/#_P63086-mappedCitation-19531493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19531493 |
| http://purl.uniprot.org/uniprot/#_A0A338P736-mappedCitation-19531493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19531493 |