| http://purl.uniprot.org/citations/19535619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19535619 | http://www.w3.org/2000/01/rdf-schema#comment | "CCL2 is a key CC chemokine that has been implicated in a variety of inflammatory autoimmune diseases and in tumor progression and it is therefore an important target for therapeutic intervention in these diseases. Soluble receptor-based therapy is a known approach for neutralizing the in vivo functions of soluble mediators. Owing to the complexity of seven-transmembrane G protein-coupled receptors, efforts to generate neutralizing soluble chemokine receptors have so far failed. We developed a strategy that is based on the generation of short recombinant proteins encoding different segments of a G protein-coupled receptor, and tested the ability of each of them to bind and neutralize its target chemokine. We show that a fusion protein comprised of as few as 20 aa of the third extracellular (E3) domain of the CCL2 receptor, stabilized by the IgG H chain Fc domain (E3-IgG or BL-2030), selectively binds CCL2 and CCL16 and effectively neutralizes their biological activities. More importantly, E3-IgG (BL-2030) could effectively suppress the in vivo biological activity of CCL2, attenuating ongoing experimental autoimmune encephalomyelitis, as well as the development of human prostate tumor in SCID mice."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0802746"xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/author | "Karin N."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/author | "Zohar Y."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/author | "Elkeles A."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/author | "Wildbaum G."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/author | "Ayalon-Soffer M."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/author | "Yefenof E."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/author | "Klapper L."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/author | "Seagal J."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/author | "Anunu R."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/author | "Izhak L."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/pages | "732-739"xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/title | "A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2."xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/19535619 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19535619 |
| http://purl.uniprot.org/citations/19535619 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19535619 |
| http://purl.uniprot.org/uniprot/#_B4XH68-mappedCitation-19535619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19535619 |
| http://purl.uniprot.org/uniprot/#_B4XH69-mappedCitation-19535619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19535619 |
| http://purl.uniprot.org/uniprot/#_P41597-mappedCitation-19535619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19535619 |
| http://purl.uniprot.org/uniprot/#_P10148-mappedCitation-19535619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19535619 |
| http://purl.uniprot.org/uniprot/#_L7REX9-mappedCitation-19535619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19535619 |