http://purl.uniprot.org/citations/19538209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19538209 | http://www.w3.org/2000/01/rdf-schema#comment | "Background and purposeA possible association between Parkinson's disease (PD) and the polymorphism of Brain Derived Neurotrophic Factor (BDNF) G196A (Val66Met) has been suggested by different studies that nevertheless yielded-contrasting result. The purpose of this study was to analyze such possible association in a cohort of Italian PD patients.MethodsThe BDNF polymorphisms were analyzed in 294 Italian patients with PD; results were compared to those obtained in 233 age- and sex-matched healthy controls (HC) enrolled from two tertiary centres in Italy. Polymorphisms were determined by Restriction Fragment Length Polymorphism (RFLP) analysis; correlations between BDNF G196A polymorphism, and cognitive function were established by sub analyzing the results upon dividing PD patients based on their Mini Mental State Examination (MMSE) score.ResultsUnivariate analysis showed a highly significant correlation between the BDNF(AA) genotype and a MMSE score < or =24. Hence, the distribution of this genotype in PD individuals with a MMSE score < or =24 was significantly increased compared to PD patients with an MMSE score >24 and HC (P < 0.001 in both cases). Multivariate analyses showed that BDNF (AA) genotype was associated to a sixfold risk of cognitive impairment.ConclusionsThe BDNF(AA) homozygote genotype is over-represented in PD patients compared with normal individuals; this genotype was significantly correlated to cognitive impairment, age and disease severity. These results, although preliminary, could be important in establishing novel diagnostic and therapeutic approaches to PD."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1468-1331.2009.02706.x"xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Clerici M."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Casali C."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Martignoni E."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Nappi G."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Guerini F.R."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Riboldazzi G."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Agliardi C."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Zangaglia R."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Di Lorenzo C."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Bono G."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Beghi E."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/author | "Pianezzola C."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/name | "Eur J Neurol"xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/pages | "1240-1245"xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/title | "BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson's disease."xsd:string |
http://purl.uniprot.org/citations/19538209 | http://purl.uniprot.org/core/volume | "16"xsd:string |
http://purl.uniprot.org/citations/19538209 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19538209 |
http://purl.uniprot.org/citations/19538209 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19538209 |
http://purl.uniprot.org/uniprot/#_A0A0E3SU01-mappedCitation-19538209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19538209 |
http://purl.uniprot.org/uniprot/#_A0A0S2Z3M9-mappedCitation-19538209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19538209 |
http://purl.uniprot.org/uniprot/#_A0A0S2Z3E7-mappedCitation-19538209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19538209 |