| http://purl.uniprot.org/citations/19538465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19538465 | http://www.w3.org/2000/01/rdf-schema#comment | "Preeclampsia (PE) is characterized by widespread endothelial damage with hypertension, proteinuria, glomeruloendotheliosis and elevated soluble Flt-1 (sFlt-1), a natural occurring antagonist of vascular endothelial growth factor (VEGF). Cancer patients receiving anti-VEGF therapy exhibit similar symptoms. We suggested that a decrease in circulating sFlt-1 would alleviate the symptoms associated with PE. Adenoviral (Adv) overexpression of sFlt-1 induced proteinuria, caused glomerular damage and increase in blood pressure in female Balb/c mice. Circulating level of sFlt-1 above 50 ng/ml plasma induced severe vascular damage and glomerular endotheliosis. Albumin concentration in urine was elevated up to 30-fold, compared to control AdvGFP-treated animals. The threshold of kidney damage was in the range of 20-30 ng/ml sFlt-1 in plasma (8-15 ng/ml in urine). Co-administration of AdvsFlt-1 with AdvVEGF to neutralize circulating sFlt-1 resulted in more than a 70% reduction in free sFlt-1 in plasma, more than 80% reduction in urine and rescued the damaging effect of sFlt-1 on the kidneys. This demonstrates that below a critical threshold sFlt-1 fails to elicit damage to the fenestrated endothelium and that co-expression of VEGF is able to rescue effects mediated by sFlt-1 overexpression."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1582-4934.2009.00820.x"xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Ahmad S."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Ahmed A."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Grone H.J."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Bergmann A."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Christofori G."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Gruber A.D."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Gross V."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Lindenmaier W."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Weich H.A."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Cudmore M."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Gonzalves A.C.h."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/author | "Wittschen P."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/name | "J Cell Mol Med"xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/pages | "1857-1867"xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/title | "Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model."xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/19538465 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19538465 |
| http://purl.uniprot.org/citations/19538465 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19538465 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0A4-mappedCitation-19538465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19538465 |
| http://purl.uniprot.org/uniprot/#_O55095-mappedCitation-19538465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19538465 |
| http://purl.uniprot.org/uniprot/#_P35969-mappedCitation-19538465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19538465 |