| http://purl.uniprot.org/citations/19539019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19539019 | http://www.w3.org/2000/01/rdf-schema#comment | "The Usher syndrome 3A (CLRN1) gene encodes clarin-1, which is a member of the tetraspanin family of transmembrane proteins. Although identified more than 6 years ago, little is known about its localization or function in the eye and ear. We developed a polyclonal antibody that react with all clarin-1 isoforms and used it to characterize protein expression in cochlea and retina. In the cochlea, we observe clarin-1expression in the stereocilia of P0 mice, and in synaptic terminals present at the base of the auditory hair cells from E18 to P6. In the retina, clarin-1 localizes to the connecting cilia, inner segment of photoreceptors and to the ribbon synapses. RT-PCR from P0 cochlea and P28 retina show mRNAs encoding only isoforms 2 and 3. Western blots show that only isoform 2 is present in protein extracts from these same tissues. We examined clarin-1 expression in the immortomouse-derived hair cell line UB/OC-1. Only isoform 2 is expressed in UB/OC-1 at both mRNA and protein levels, suggesting this isoform is biologically relevant to hair cell function. The protein co-localizes with microtubules and post-transgolgi vesicles. The subcellular localization of clarin-1 in hair cells and photoreceptors suggests it functions at both the basal and apical poles of neurosensoriepithelia."xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.heares.2009.06.006"xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/author | "Askew C."xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/author | "Meehan D.T."xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/author | "Cosgrove D."xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/author | "Delimont D."xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/author | "Gratton M.A."xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/author | "Zallocchi M."xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/author | "Garige S."xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/author | "Rothermund-Franklin C.A."xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/name | "Hear Res"xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/pages | "109-120"xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/title | "Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors."xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://purl.uniprot.org/core/volume | "255"xsd:string |
| http://purl.uniprot.org/citations/19539019 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19539019 |
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| http://purl.uniprot.org/uniprot/#_O88935-mappedCitation-19539019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19539019 |
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| http://purl.uniprot.org/uniprot/#_Q8K445-mappedCitation-19539019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19539019 |